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KMID : 0356919960300060711
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Korean Journal of Anesthesiology
1996 Volume.30 No. 6 p.711 ~ p.714
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The Effect of Neostigmine on the Train-of-four Ratio during the Recovery from Vecuronium - or Atracurium-induced Neuromuscular Blockade
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Abstract
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Background:
@EN The train-of-four(TOF) fade known as expression of prejuntional receptor binding was useful for evaluating the residual neuromuscular blockade(NMB). The present study was undertaken to investigate the effect of the neostigmine(Neo) on TOF
ratio
during the recovery from vecuronium (V) or atracurium(A) induced NMB under the general anesthesia.
@ES Methods:
@EN Forty healthy adult patients were randomly divided into 4 groups as follows; spontaneous recovery from V-induced NMB(V-C group) or A-induced NMB(A-C group), reversed recovery with Neo at 20% recovery of control first twitch height(T1) from
V-induced
NMB(V-R group) or A-induced NMB(A-R group). TOF ratio at 25 and 75% recovery of T1 and recovery index(RT) defined as time from 25to 75% recovery of T1 were measured.
@ES Results:
@EN TOF ratios at 25 and 75% recovery of T1 were 3.7 & 35.8%(V-C group), 8.4 & 46.9% (A-C group), 3.7& 48.7% (V-R group) and 15.2 & 55.6%(A-R group) respectively(P>0.05). RI were 19.2 min(V-C group), 19.5 min(A-C group), 3.5 min(V-R group), and
5.6
min(A-R group) respectively (P<0.05).
@ES Conclusions:
@EN RI were significant shortened in reversed recovery groups with Neo than spontaneous recovery groups (P<0.05). However TOF ratio at 75% recovery of T1 were not significantly different between spontaneous recovery and reversed recovery groups.
(Koran
J Anesthesiol 1996; 30: 711~714)
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